abstract：:Since their introduction to biological imaging, quantum dots (QDs) have progressed from a little known, but attractive, technology to one that has gained broad application in many areas of biology. The versatile properties of these fluorescent nanoparticles have allowed investigators to conduct biological studies with...

journal_title：Cell and tissue research

authors： Vu TQ,Lam WY,Hatch EW,Lidke DS

更新日期：2015-04-01 00:00:00

abstract：:We have recently reported that Sox2-expressing pituitary stem/progenitor cells contact each other via a tight-junction protein CAR to form stem/progenitor cell niches in the marginal cell layer facing the lumen and in the clusters scattered in the parenchyma of the anterior lobe. However, the microenvironment of the n...

journal_title：Cell and tissue research

authors： Yoshida S,Kato T,Higuchi M,Chen M,Ueharu H,Nishimura N,Kato Y

更新日期：2015-03-01 00:00:00

abstract：:Steroid hormones intervene in the structural and functional regulation of neuronal processes during development and thus determine brain differentiation. The effects of estrogens are mediated by two transcription factors, namely estrogen receptor α (ER-α) and estrogen receptor β (ER-β), that regulate the expression of...

journal_title：Cell and tissue research

authors： Panin M,Corain L,Montelli S,Cozzi B,Peruffo A

更新日期：2015-02-01 00:00:00

abstract：:In the developing mammalian nervous system, common progenitors integrate both cell extrinsic and intrinsic regulatory programs to produce distinct neuronal and glial cell types as development proceeds. This spatiotemporal restriction of neural progenitor differentiation is enforced, in part, by the dynamic reorganizat...

journal_title：Cell and tissue research

authors： Corley M,Kroll KL

更新日期：2015-01-01 00:00:00

abstract：:Wnts are secreted glycoproteins that play multiple roles in early development, including the differentiation of precursor cells. During this period, gradients of Wnts and other morphogens are formed and regulate the differentiation and migration of neural progenitor cells. Afterwards, Wnt signalling cascades participa...

journal_title：Cell and tissue research

authors： Inestrosa NC,Varela-Nallar L

更新日期：2015-01-01 00:00:00

abstract：:Ex-fissiparous planarians produce infertile cocoons or, in very rare cases, cocoons with very low fertility. Here, we describe the features of programmed cell death (PCD) occurring in the hyperplasic ovary of the ex-fissiparous freshwater planarian Dugesia arabica that may explain this infertility. Based on TEM result...

journal_title：Cell and tissue research

authors： Harrath AH,Semlali A,Mansour L,Ahmed M,Sirotkin AV,Al Omar SY,Arfah M,Al Anazi MS,Alhazza IM,Nyengaard JR,Alwasel S

更新日期：2014-11-01 00:00:00

abstract：:Homeobox genes encode transcription factors that regulate embryonic development programs including organogenesis, axis formation and limb development. Previously, we identified and cloned a mouse double homeobox gene, Duxbl, whose homeodomain exhibits the highest identity (67 %) to human DUX4, a candidate gene of faci...

journal_title：Cell and tissue research

authors： Wu SL,Li GZ,Chou CY,Tsai MS,Chen YP,Li CJ,Liou GG,Chang WW,Chen SL,Wang SH

更新日期：2014-11-01 00:00:00

abstract：:During the formation of dental enamel, maturation-stage ameloblasts express ion-transporting transmembrane proteins. The SLC4 family of ion-transporters regulates intra- and extracellular pH in eukaryotic cells by cotransporting HCO3 (-) with Na(+). Mutation in SLC4A4 (coding for the sodium-bicarbonate cotransporter N...

journal_title：Cell and tissue research

authors： Jalali R,Guo J,Zandieh-Doulabi B,Bervoets TJ,Paine ML,Boron WF,Parker MD,Bijvelds MJ,Medina JF,DenBesten PK,Bronckers AL

更新日期：2014-11-01 00:00:00

abstract：:Receptors for advanced glycation end-products (RAGE) are members of the immunoglobulin superfamily of cell-surface receptors implicated in mechanisms of pulmonary inflammation. In the current study, we test the hypothesis that RAGE mediates inflammation in primary alveolar macrophages (AMs) exposed to diesel particula...

journal_title：Cell and tissue research

authors： Barton DB,Betteridge BC,Earley TD,Curtis CS,Robinson AB,Reynolds PR

更新日期：2014-10-01 00:00:00

abstract：:Kruppel-like factor 4 (KLF4) is a zinc-finger-type transcription factor with a restricted expression pattern during skeletal development. We have previously shown that KLF4 represses osteoblast mineralization concomitant with a down-regulation in the expression of a number of osteoblastic genes, both in vivo and in vi...

journal_title：Cell and tissue research

authors： Fujikawa J,Tanaka M,Itoh S,Fukushi T,Kurisu K,Takeuchi Y,Morisaki I,Wakisaka S,Abe M

更新日期：2014-10-01 00:00:00

abstract：:The carotid body is a peripheral chemoreceptor that detects decreases in arterial pO2 and subsequently activates the carotid sinus nerve. The hypoxia-evoked activity of the carotid sinus nerve has been suggested to be modulated by glutamate. In the present study, we investigate the immunohistochemical localization of ...

journal_title：Cell and tissue research

authors： Yokoyama T,Nakamuta N,Kusakabe T,Yamamoto Y

更新日期：2014-10-01 00:00:00

abstract：:The association between adipose tissue and immunity has been established and fat-associated lymphoid clusters (FALCs) are considered as a source of immune cells. We discovered lymphoid clusters (LCs) in mouse mediastinal fat tissues (MFTs). In Th1-biased C57BL/6N (B6), Th2-biased DBA/2Cr (DBA) and autoimmune-prone MRL...

journal_title：Cell and tissue research

authors： Elewa YH,Ichii O,Otsuka S,Hashimoto Y,Kon Y

更新日期：2014-09-01 00:00:00

abstract：:Some non-endocrine cells in the pituitary anterior lobe are responsible for providing stem/progenitor cells to maintain hormone-producing cells. In particular, cells expressing S100β protein, a calcium-binding protein, have been hypothesized to be a pituitary cell resource. Accumulating data have revealed that S100β-p...

journal_title：Cell and tissue research

authors： Higuchi M,Kanno N,Yoshida S,Ueharu H,Chen M,Yako H,Shibuya S,Sekita M,Tsuda M,Mitsuishi H,Nishimura N,Kato T,Kato Y

更新日期：2014-09-01 00:00:00

abstract：:Semaphorin 3A (Sema3A) axon repellant serves multiple developmental functions. Sema3A mRNAs are expressed in epithelial and mesenchymal components of the developing incisor in a dynamic manner. Here, we investigate the functions of Sema3A during development of incisors using Sema3A-deficient mice. We analyze histomorp...

journal_title：Cell and tissue research

authors： Shrestha A,Moe K,Luukko K,Taniguchi M,Kettunen P

更新日期：2014-07-01 00:00:00

abstract：:Post-translational modification of histone proteins, such as the methylation of lysine and arginine residues, influences the higher order of chromatin and leads to gene activation or silencing. Histone methyltransferases or demethylases actively add or remove various methylation marks in a cell-type-specific and conte...

journal_title：Cell and tissue research

authors： Roidl D,Hacker C

更新日期：2014-06-01 00:00:00

abstract：:Long-non-coding RNA (lncRNA) regulates gene expression through transcriptional and epigenetic regulation as well as alternative splicing in the nucleus. In addition, regulation is achieved at the levels of mRNA translation, storage and degradation in the cytoplasm. During recent years, several studies have described t...

journal_title：Cell and tissue research

authors： Backofen R,Vogel T

更新日期：2014-06-01 00:00:00

abstract：:The Sgcb-null mouse, with knocked-down β-sarcoglycan, develops severe muscular dystrophy as in type 2E human limb girdle muscular dystrophy. The mdx mouse, lacking dystrophin, is the most used model for Duchenne muscular dystrophy (DMD). Unlike DMD, the mdx mouse has mild clinical features and shows little fibrosis in...

journal_title：Cell and tissue research

authors： Gibertini S,Zanotti S,Savadori P,Curcio M,Saredi S,Salerno F,Andreetta F,Bernasconi P,Mantegazza R,Mora M

更新日期：2014-05-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell (MSC) characterized by multi-lineage differentiation making it an attractive choice for tissue regeneration. However, before DPSCs can be used for cell-based therapy, we have to understand their biological properties in response to intrinsic and extrin...

journal_title：Cell and tissue research

authors： Feng X,Feng G,Xing J,Shen B,Tan W,Huang D,Lu X,Tao T,Zhang J,Li L,Gu Z

更新日期：2014-05-01 00:00:00

abstract：:PRDM1 (PR domain containing 1) is a transcriptional repressor that has been identified in various species and is crucial for cell growth, differentiation and development. However, the expression pattern and role of PRDM1 in development has not been sufficiently established in birds. We therefore investigate the spatio...

journal_title：Cell and tissue research

authors： Wan Z,Rui L,Li Z

更新日期：2014-05-01 00:00:00

abstract：:Sigma receptor 1 (σR1), a non-opiate transmembrane protein located on endoplasmic reticulum (ER) and mitochondrial membranes, is considered to be a molecular chaperone. Marked protection against cell death has been observed when ligands for σR1 have been used in in vitro and in vivo models of retinal cell death. Mice ...

journal_title：Cell and tissue research

authors： Ha Y,Shanmugam AK,Markand S,Zorrilla E,Ganapathy V,Smith SB

更新日期：2014-04-01 00:00:00

abstract：:In the context of cell-based oral hard tissue regeneration, especially assumed plasticity of oral host tissue cells in response to human mesenchymal stem cells (hMSCs), is poorly understood. To investigate this area, we assess osteogenic features in various oral cell types during hMSC coculture, including human alveol...

journal_title：Cell and tissue research

authors： Proksch S,Steinberg T,Vach K,Hellwig E,Tomakidi P

更新日期：2014-04-01 00:00:00

abstract：:During the first postnatal weeks of the developing rodent retina, rhodopsin can be detected in a number of neuron-like cells in the inner retina. In the present study, we aim to characterize the morphology, number and staining characteristics of this peculiar population. Misplaced rhodopsin-positive cells (MRCs) were ...

journal_title：Cell and tissue research

authors： Szabó K,Szabó A,Enzsöly A,Szél A,Lukáts A

更新日期：2014-04-01 00:00:00

abstract：:The endothelial layer of blood vessels controls the passage of cells and solutes from the blood into the surrounding tissue. Crucial for this regulation is the integrity of endothelial cell-cell junctions. Various molecular mechanisms control junctional integrity of the endothelial layer including GTPases, modulation ...

journal_title：Cell and tissue research

authors： Küppers V,Vockel M,Nottebaum AF,Vestweber D

更新日期：2014-03-01 00:00:00

abstract：:The blood-brain barrier (BBB) protects the brain from toxic substances within the bloodstream and keeps the brain's homeostasis stable. On the other hand, it also represents the main obstacle in the treatment of many CNS diseases. Among different techniques, nanoparticles have emerged as promising tools to enhance bra...

journal_title：Cell and tissue research

authors： Rempe R,Cramer S,Qiao R,Galla HJ

更新日期：2014-03-01 00:00:00

abstract：:Many noctuid moth species perceive ultrasound via tympanic ears that are located at the metathorax. Whereas the neural processing of auditory information is well studied at the peripheral and first synaptic level, little is known about the features characterizing higher order sound-sensitive neurons in the moth brain....

journal_title：Cell and tissue research

authors： Pfuhl G,Zhao XC,Ian E,Surlykke A,Berg BG

更新日期：2014-02-01 00:00:00

abstract：:Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this ...

journal_title：Cell and tissue research

authors： Titorencu I,Pruna V,Jinga VV,Simionescu M

更新日期：2014-01-01 00:00:00

abstract：:Ontogenesis comprises a series of events including cell proliferation and apoptosis and resulting in the normal development of the embryo. Protein p53 has been described as being involved in the development of several animal species. The aim of this study was to analyze the expression of protein p53 during the morphog...

journal_title：Cell and tissue research

authors： Ventura A,do Nascimento AA,dos Santos MA,Vieira-Lopes DA,Sales A,Pinheiro NL

更新日期：2014-01-01 00:00:00

abstract：:Whether environmental exposure to bisphenol A (BPA) may induce reproductive disorders is still controversial but certain studies have reported that BPA may cause meiotic abnormalities in C. elegans and female mice. However, little is known about the effect of BPA on meiosis in adult males. To determine whether BPA exp...

journal_title：Cell and tissue research

authors： Liu C,Duan W,Zhang L,Xu S,Li R,Chen C,He M,Lu Y,Wu H,Yu Z,Zhou Z

更新日期：2014-01-01 00:00:00

abstract：:Dexamethasone (Dex) regulates osteoblastic and adipocytic differentiation in mesenchymal progenitor cells through regulation of Wnt/β-catenin signaling. To elucidate the regulatory mechanisms underlying the effects of Dex, we examine the expression of Axin2, which is an intracellular inhibitor of Wnt/β-catenin signali...

journal_title：Cell and tissue research

authors： Naito M,Mikami Y,Takagi M,Takahashi T

更新日期：2013-12-01 00:00:00

abstract：:We develop "autologous bone marrow cell infusion (ABMi) therapy" for the treatment of human decompensated liver cirrhosis and confirm the efficacy and safety of this treatment in multicenter clinical studies. With the goal of further expanding the applications of ABMi, we first cultured human bone marrow cells and the...

journal_title：Cell and tissue research

authors： Tanimoto H,Terai S,Taro T,Murata Y,Fujisawa K,Yamamoto N,Sakaida I

更新日期：2013-12-01 00:00:00

abstract：:Satellite cells can be isolated from skeletal muscle biopsies, activated to proliferating myoblasts and differentiated into multinuclear myotubes in culture. These cell cultures represent a model system for intact human skeletal muscle and can be modulated ex vivo. The advantages of this system are that the most relev...

journal_title：Cell and tissue research

authors： Aas V,Bakke SS,Feng YZ,Kase ET,Jensen J,Bajpeyi S,Thoresen GH,Rustan AC

更新日期：2013-12-01 00:00:00

abstract：:The bursa of Fabricius of the chicken is known to be both a primary lymphoid organ and a secondary lymphoid tissue. Bursal follicles are equipped with antigen-trapping follicle-associated epithelium. However, bioactive antigens such as protein and bacteria have not been detected in the bursal parenchyma. By immunopero...

journal_title：Cell and tissue research

authors： Sonoda K,Noguchi K,Ekino S

更新日期：2013-12-01 00:00:00

abstract：:The size of various tubes within tubular organs such as the lung, vascular system and kidney must be finely tuned for the optimal delivery of gases, nutrients, waste and cells within the entire organism. Aberrant tube sizes lead to devastating human illnesses, such as polycystic kidney disease, fibrocystic breast dise...

journal_title：Cell and tissue research

authors： Zuo L,Iordanou E,Chandran RR,Jiang L

更新日期：2013-11-01 00:00:00

abstract：:Mice and rats emit and perceive calls in the ultrasonic range, i.e., above the human hearing threshold of about 20 kHz: so-called ultrasonic vocalizations (USV). Juvenile and adult rats emit 22-kHz USV in aversive situations, such as predator exposure and fighting or during drug withdrawal, whereas 50-kHz USV occur in...

journal_title：Cell and tissue research

authors： Wöhr M,Schwarting RK

更新日期：2013-10-01 00:00:00

abstract：:The startle is a relatively simple ubiquitous reflex. Interestingly, it has a "non-zero baseline", i.e., its magnitude can be reduced or enhanced. We reflect here on the translational value of prepulse inhibition and fear-related potentiation as endophenotypes that can be used for the investigation of complex psychiat...

journal_title：Cell and tissue research

authors： Fendt M,Koch M

更新日期：2013-10-01 00:00:00

abstract：:Four forms of short neuropeptide F (sNPF1-4), derived from the gene snpf, have been identified in Drosophila and are known to act on a single G-protein-coupled receptor (sNPFR). Several functions have been suggested for sNPFs in Drosophila, including the regulation of feeding and growth in larvae, the control of insul...

journal_title：Cell and tissue research

authors： Carlsson MA,Enell LE,Nässel DR

更新日期：2013-09-01 00:00:00

abstract：:Synaptogyrins are conserved components of the exocytic apparatus and function as regulators of Ca(2+)-dependent exocytosis. The synaptogyrin family comprises three isoforms: two neuronal (synaptogyrin-1 and -3) and one ubiquitous (synaptogyrin-2) form. Although the expression patterns of the exocytic proteins synaptot...

journal_title：Cell and tissue research

authors： Kotani T,Toyono T,Seta Y,Kitou A,Kataoka S,Toyoshima K

更新日期：2013-09-01 00:00:00

abstract：:The fine structure and primary sensory projections of sensilla located in the labial-palp pit organ of the cotton bollworm Helicoverpa armigera (Insecta, Lepidoptera) are investigated by scanning electron and transmission electron microscopy combined with confocal laser scanning microscopy. The pit organ located on th...

journal_title：Cell and tissue research

authors： Zhao XC,Tang QB,Berg BG,Liu Y,Wang YR,Yan FM,Wang GR

更新日期：2013-09-01 00:00:00

abstract：:Glaucoma, a disease of the optic nerve and retina, causes blindness in millions of people worldwide. Currently available therapies for this disease only attempt to reduce intraocular pressure, the major risk factor, without addressing the associated optic neuropathy and retinopathy. Development of glaucoma neuroprotec...

journal_title：Cell and tissue research

authors： Liu Y,Pang IH

更新日期：2013-08-01 00:00:00

abstract：:Many efforts have been made to improve the diagnostic tools used to identify and to estimate the progress of ganglion cell and nerve fibre degeneration in glaucoma. Imaging by optical coherence tomography and measurements of the dimensions of the optic nerve head and the nerve fibre layer in central retinal areas is c...

journal_title：Cell and tissue research

authors： Prasse M,Rauscher FG,Wiedemann P,Reichenbach A,Francke M

更新日期：2013-08-01 00:00:00